AI Article Synopsis
- Peripheral blood lymphocytes show impaired cAMP metabolism during acute malaria, which improves after parasite clearance.
- Decreased cAMP levels and reduced response to stimulants like adenosine or forskolin were observed.
- These changes correlate with lower lymphocyte proliferation in response to concanavalin A, suggesting a link between cAMP defects and immunosuppression during malaria infection.
Article Abstract
Peripheral blood lymphocytes were observed to have a defect in adenosine 3',5'-monophosphate (cAMP) metabolism during acute malaria infection which reversed once parasites were eliminated from the host circulation. The defect was characterized by decreased intracellular cAMP levels in lymphocytes and by hyporesponsiveness to adenosine or forskolin stimulation of cAMP production. These biochemical changes appeared to correlate functionally with a reduction in the proliferative response of lymphocytes to concanavalin A. A defect in the second messenger role of cAMP in immune effector cells may underlie immunosuppression in malaria infection.
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| http://dx.doi.org/10.1016/0162-3109(90)90066-n | DOI Listing |
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