AI Article Synopsis
- The study aims to establish the marine medaka fish, Oryzias melastigma, as a model for researching innate immunity and immunotoxicity.
- Researchers identified two hepcidin genes (OM-hep1 and OM-hep2) in the fish, which are crucial for the immune response and show strong similarity to hepcidins in other species.
- The expression of these hepcidin transcripts varies in different tissues and significantly increases in response to bacterial infections, highlighting their role in immune defense and suggesting that gender differences should be accounted for in related studies.
Article Abstract
The objective of this study is to develop the marine medaka Oryzias melastigma as a potential marine fish model for innate immune and immunotoxicological studies. Hepcidin plays an important role in innate immune system. Two hepcidin genes (OM-hep1 and OM-hep2) were identified and characterized in the O. melastigma, which were highly conserved with other reported hepcidins. During embryogenesis, significant elevation of OM-hep1 and OM-hep2 transcripts were coincided with liver development in the embryos. In adult medaka, differential tissue expressions of both hepcidin transcripts were evident: high in liver, moderate in spleen and low in non-immune tissues. After bacterial challenge, the two hepcidin mRNAs were rapidly and remarkably induced in liver and spleen, suggesting the two OM-hepcidins in O. melastigma play a complementary role in innate defense. Gender difference in time of induction and extent of the two hepcidin mRNAs elevation in infected O. melastigma should be considered in immunotoxicological studies.
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| http://dx.doi.org/10.1016/j.marpolbul.2011.05.014 | DOI Listing |
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