Alterations in cyclic GMP levels in preeclampsia may reflect increased B-type natriuretic peptide levels and not impaired nitric oxide activity.

Clin Biochem

Núcleo de Pós-Graduação e Pesquisa, Santa Casa de Belo Horizonte, Av. Francisco Sales 1111, Belo Horizonte, MG, Brazil.

Published: August 2011

Objectives: We compared nitrite, B-type natriuretic peptide (BNP), and cGMP levels in preeclamptic with those found in healthy pregnant.

Methods: We studied 21 healthy pregnant and 27 preeclamptic. Plasma cGMP and BNP levels were determined by ELISA. Nitrite levels were determined by chemiluminescence.

Results: Higher cGMP and BNP, and lower nitrite levels were found in preeclamptic versus healthy pregnant.

Conclusions: Altered cGMP levels reflect increased BNP levels and not impaired nitric oxide activity in preeclampsia.

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Source
http://dx.doi.org/10.1016/j.clinbiochem.2011.05.026DOI Listing

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