AI Article Synopsis
- All organisms have mechanisms to repair their DNA, which is crucial for their survival and the survival of their offspring; these mechanisms can also lead to genetic diversity.
- Sequencing of bacteria has shown significant genetic variation even within the same species, emphasizing the need to understand how DNA recombination and repair work.
- Helicobacter pylori, a pathogen that infects the human stomach, is a valuable model for studying these processes due to its capacity for genetic diversification through recombination and repair pathways.
Article Abstract
All organisms have pathways that repair the genome, ensuring their survival and that of their progeny. But these pathways also serve to diversify the genome, causing changes at the nucleotide, whole gene, and genome structure levels. Sequencing of bacteria has revealed wide allelic diversity and differences in gene content within the same species, highlighting the importance of understanding pathways of recombination and DNA repair. The human stomach pathogen Helicobacter pylori is an excellent model system for studying these pathways. H. pylori harbors major recombination and repair pathways and is naturally competent, facilitating its ability to diversify its genome. Elucidation of DNA recombination, repair, and diversification programs in this pathogen will reveal connections between these pathways and their importance to infection.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3743418 | PMC |
| http://dx.doi.org/10.1146/annurev-micro-090110-102931 | DOI Listing |
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