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Modeling Malignant Mesothelioma in Genetically Engineered Mice.
Curr Protoc
January 2025
Cancer Prevention and Control Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania.
Mesothelioma is a lethal cancer of the serosal lining of the body cavities. Risk factors include environmental and genetic factors. Asbestos exposure is considered the principal environmental risk factor, but other carcinogenic mineral fibers, such as erionite, also have a causal role.
View Article and Find Full Text PDFThoracic aortic coarctation with asbestos-induced pleural fibrosis presenting as lower limb claudication.
Acta Chir Belg
October 2024
Vascular Surgery Department, Parc Tauli Hospital Universitari, Sabadell, Spain.
Asbestos exposure is a well-documented cause of pulmonary diseases. However, its systemic effects, particularly on the cardiovascular system, are less understood. We expose a case that highlights an unusual cardiovascular manifestation in a patient with a history of pleural asbestosis compressing the aorta and clinically manifested as lower limb claudication.
View Article and Find Full Text PDFTargeting inflammatory factors for chemoprevention and cancer interception to tackle malignant mesothelioma.
Oncoscience
May 2024
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111, USA.
Mesothelioma is an incurable cancer of the mesothelial lining often caused by exposure to asbestos. Asbestos-induced inflammation is a significant contributing factor in the development of mesothelioma, and genetic factors also play a role in the susceptibility to this rapidly progressive and treatment-resistant malignancy. Consequently, novel approaches are urgently needed to treat mesothelioma and prevent or reduce the overall incidence of this fatal disease.
View Article and Find Full Text PDFThe MexTAg collaborative cross: host genetics affects asbestos related disease latency, but has little influence once tumours develop.
Front Toxicol
April 2024
National Centre for Asbestos Related Diseases (NCARD), Perth, WA, Australia.
This study combines two innovative mouse models in a major gene discovery project to assess the influence of host genetics on asbestos related disease (ARD). Conventional genetics studies provided evidence that some susceptibility to mesothelioma is genetic. However, the identification of host modifier genes, the roles they may play, and whether they contribute to disease susceptibility remain unknown.
View Article and Find Full Text PDFWhole-Genome Comparative Copy Number Alteration Profiling between Malignant Pleural Mesothelioma and Asbestos-Induced Chronic Pleuritis.
J Environ Pathol Toxicol Oncol
November 2023
Eskisehir Osmangazi University Medical Faculty, Department of Medical Biology, Eskisehir, Turkey.
Malignant pleural mesothelioma (MPM) is rare and aggressive cancer. The most important risk factor for MPM is exposure to asbestos. In this study, we scanned the genomes of individuals MPM and asbestos-induced chronic pleuritis (AICP) to compare and determine copy number alterations (CNAs) between two asbestos-related diseases.
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