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[Extra-membranous glomerulonephritis: report of a family and new physiopathological concepts].
Bull Acad Natl Med
April 2004
Unité INSERM 489, Hôpital Tenon, 4 rue de la Chine, 75020 Paris.
Membranous glomerulonephritis (MGN) is a major cause of the nephrotic syndrome and chronic renal insufficiency. Studies on the reactivity of nephritogenic antibodies implicated in a case of antenatal MGN led to identify for the first time a target of the immune conflict in glomeruli, neutral endopeptidase (CD10). This enzyme that is restricted to certain tissues, being strongly expressed in the placenta and on glomerular podocytes, is involved in the catabolism of a number of regulatory peptides, particularly those involved in vasomotricity.
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