AI Article Synopsis
- The ongoing debate in the scientific community about antibiotic pressure's role in antibiotic-resistant bacteria is complicated by limited data on antibiotic usage, emphasizing the need for careful management in intensive care units (ICUs).
- Prior antibiotic exposure increases the risk of patients becoming colonized and infected with resistant bacteria, which is particularly concerning due to the high mortality rates associated with these infections in critically ill patients.
- Implementing antibiotic stewardship programs (ASP) has shown promise in reducing inappropriate antibiotic use, but it's crucial to consider local ecology and to establish effective strategies at both national and international levels.
Article Abstract
The role of antibiotic pressure in the selection of antibiotic-resistant bacteria is still under debate in the scientific community and often confounded by scarce data on antibiotic usage. Several studies demonstrated that prior antibiotic exposure is likely to increase patient's colonization and infection by antimicrobial-resistant bacteria. Of even more concern is the significant mortality associated with these infections, in particular in critically ill patients. Therefore, the control of antibiotic usage in intensive care units (ICUs) is of paramount importance. Antibiotic stewardship programmes (ASP) have been demonstrated to represent a useful intervention to reduce the inappropriate antibiotic usage in hospitalized patients. A few trials were performed in ICU population with positive results. The major risk we foresee for the implementation of ASP for ICU patients is the lack of consideration of local ecology and strict quality indicators. The development of new pattern of antimicrobial resistance might be ascribed to an inappropriate ASP. European networks to define best strategies and antibiotic-care bundles need to be supported at national and international level. To optimize antibiotic use in the ICU and to fight against the spread of resistance, it is extremely important to adopt a multifaceted approach including ASP.
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| http://dx.doi.org/10.2174/187152611796504791 | DOI Listing |
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