AI Article Synopsis
- Pneumocystis jirovecii is known to cause pneumonia primarily in immunosuppressed patients, but low levels of its DNA have been detected in those without symptoms, suggesting possible colonization.
- Research indicates that Pneumocystis triggers both local and systemic responses in the body, affecting immune reactions.
- The report reviews the potential role of P. jirovecii colonization in chronic pulmonary diseases like COPD, interstitial lung diseases, cystic fibrosis, and lung cancer, indicating its possible impact on disease progression.
Article Abstract
Pneumocystis jirovecii causes pneumonia in immunosuppressed individuals. However, it has been reported the detection of low levels of Pneumocystis DNA in patients without signs and symptoms of pneumonia, which likely represents colonization. Several studies performed in animals models and in humans have demonstrated that Pneumocystis induces a local and a systemic response in the host. Since P jirovecii colonization has been found in patients with chronic pulmonary diseases it has been suggested that P jirovecii may play a role in the physiopathology and progression of those diseases. In this report we revise P. jirovecii colonization in different chronic pulmonary diseases such us, chronic obstructive pulmonary disease, interstitial lung diseases, cystic fibrosis and lung cancer.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3671413 | PMC |
| http://dx.doi.org/10.1051/parasite/2011182121 | DOI Listing |
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