Eight new flavonoids, including three pterocarpene derivatives, hirtellanines C-E, two flavanones, hirtellanines F and G, three isoflavanones, hirtellanines H-J, as well as four known compounds were isolated from the roots of Campylotropis hirtella. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D-NMR techniques. Pharmacological investigation indicated that the new compounds, particularly hirtellanines D and G, possessed potent immunosuppressive activities and low relative cytotoxicities.
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http://dx.doi.org/10.1055/s-0030-1271185 | DOI Listing |
Metabolites
September 2024
College of Life Science and Biotechnology, Mianyang Normal University, Mianxing Road West 166, Mianyang 621000, China.
Drylands cover more than 40% of global land surface and will continue to expand by 10% at the end of this century. Understanding the resistance mechanisms of native species is of particular importance for vegetation restoration and management in drylands. In the present study, metabolome of a dominant shrub in a dry-hot valley were investigated.
View Article and Find Full Text PDFJ Asian Nat Prod Res
August 2021
Institute of Materia Medica, Dali University, Dali 671000, China.
A new prenylated coumestan, campylohirtin A (), along with fifteen phenolic known compounds () and four other known compounds (), was obtained from the 95% ethanol extract of roots of . Their structures were elucidated based on extensive spectroscopic analysis (1 D and 2 D-NMR, MS, UV and IR). antimalarial activities of compounds -, - and were evaluated by -hematin formation inhibition assay.
View Article and Find Full Text PDFPlanta Med
May 2016
School of Pharmacy, Shanghai Jiao Tong University, Shanghai, P. R. China.
A phytochemical investigation on the roots of Campylotropis hirtella afforded nine new isoflavones (3-9, 12, 15), two new isoflavans (10 and 11), one new coumestan (1), and three new prenylated benzoic acid derivatives (2, 13, 14), together with twenty-four known compounds. Their structures were established by spectroscopic analysis and circular dichroism data. The isolated compounds were also evaluated for their antibacterial activities against Enterococcus faecalis, Salmonella gallinarum, Streptococcus suis, Streptococcus agalactiae, Aeromonas hydrophila, Pseudomonas aeruginosa, Bacillus subtilis, Riemerella anatipestifer, and Vibrio alginolyticus.
View Article and Find Full Text PDFFitoterapia
June 2014
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, PR China; School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, PR China. Electronic address:
In an effort to identify natural compounds with immunosuppressive activity, nine new flavonoids, including one isoflav-3-ene derivative (1), one coumaronochromone (2), two isoflavanones (3, 4), one isoflavone derivative (6), one isoflavone (7), three flavonols (8, 9, 10), as well as one known compound, hydroisoflavone C (5), were isolated from the roots of Campylotropis hirtella. The structures of these compounds were elucidated by extensive spectroscopic measurements. All of the compounds were assessed for immunosuppressive activity.
View Article and Find Full Text PDFPlanta Med
November 2011
School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, People's Republic of China.
Eight new flavonoids, including three pterocarpene derivatives, hirtellanines C-E, two flavanones, hirtellanines F and G, three isoflavanones, hirtellanines H-J, as well as four known compounds were isolated from the roots of Campylotropis hirtella. The structures of the new compounds were elucidated by spectroscopic analyses, including 2D-NMR techniques. Pharmacological investigation indicated that the new compounds, particularly hirtellanines D and G, possessed potent immunosuppressive activities and low relative cytotoxicities.
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