The efficient synthesis of 3-O-thia-cPAs (4a-d), sulfur analogues of cyclic phosphatidic acid (cPA), has been achieved. The key step of the synthesis is an intramolecular Arbuzov reaction to construct the cyclic thiophosphate moiety. The present synthetic route enables the synthesis of 4a-d in only four steps from the commercially available glycidol. Preliminary biological experiments showed that 4a-d exhibited a similar inhibitory effect on autotaxin (ATX) as original cPA.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2011.05.083 | DOI Listing |
Publication Analysis
Top Keywords
efficient synthesis
8
synthesis 3-o-thia-cpa
4
3-o-thia-cpa preliminary
4
preliminary analysis
4
analysis biological
4
biological activity
4
activity autotaxin
4
autotaxin efficient
4
synthesis 3-o-thia-cpas
4
3-o-thia-cpas 4a-d
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!