Therapeutic properties of Dead Sea Water (DSW) in the treatment of skin diseases such as atopic dermatitis, psoriasis and photo aging UV damaged skin have been well established. DSW is in fact rich in minerals such as calcium, magnesium, sodium, potassium, zinc and strontium which are known to exploit anti-inflammatory effects and to promote skin barrier recovery. In order to develop a Dead Sea Minerals (DSM) based drug delivery system for topical therapy of skin diseases, polymeric nanoparticles based on Poly (maleic anhydride-alt-butyl vinyl ether) 5% grafted with monomethoxy poly(ethyleneglycol) 2000 MW (PEG) and 95% grafted with 2-methoxyethanol (VAM41-PEG) loaded with DSM were prepared by means of a combined miniemulsion/solvent evaporation process. The resulting nanoparticles were characterized in terms of dimension, morphology, biocompatibility, salt content and release. Cytocompatible spherical nanoparticles possessing an average diameter of about 300 nm, a time controlled drug release profile and a high formulation yield were obtained.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.colsurfb.2011.05.024 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Natural Bioactive Compounds Exerting Health-Promoting Effects by Ameliorating Oxidative Stress.
Antioxidants (Basel)
January 2025
Guangdong Provincial Key Laboratory IRADS, Department of Life Sciences, BNU-HKBU United International College, Zhuhai 519087, China.
Oxidative stress is caused by various intrinsic and extrinsic factors [...
View Article and Find Full Text PDFCharacterisation of Strains and Their Prophages That Carry Horse-Specific Leukocidin Genes .
Toxins (Basel)
January 2025
Leibniz Institute of Photonic Technology (Leibniz-IPHT), Leibniz Center for Photonics in Infection Research (LPI), Germany and InfectoGnostics Research Campus, 07745 Jena, Germany.
Leukocidins of (.) are bicomponent toxins that form polymeric pores in host leukocyte membranes, leading to cell death and/or triggering apoptosis. Some of these toxin genes are located on prophages and are associated with specific hosts.
View Article and Find Full Text PDFDeep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects.
Mar Drugs
January 2025
Center for Molecular Metabolism, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, 200 Xiaolingwei Street, Nanjing 210094, China.
Neuroinflammation and neuronal cell death are leading causes of death in the elderly and underlie various neurodegenerative diseases. These diseases involve complex pathophysiological mechanisms, including inflammatory responses, oxidative stress, and ferroptosis. Compounds derived from deep-sea fungi exhibit low toxicity and potent neuroprotective effects, offering a promising source for drug development.
View Article and Find Full Text PDFSpacer Designs for Improved Hydrodynamics and Filtration Efficiency in Sea Water Reverse Osmosis.
Membranes (Basel)
January 2025
Environmental Science and Engineering Program, Division of Biological and Environmental Science and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia.
Reverse osmosis (RO) filtration performance is heavily influenced by the design of the feed spacer. Spacer design impacts hydrodynamic patterns within the system, affecting water production and concentration polarization. Two spacer designs, namely pillar (P) and standard (S), were investigated to improve the performance of a commercially available spacer design (C) in the RO process.
View Article and Find Full Text PDFPerceptual Disturbances and Disorders in the ICD-11: An Overview and a Proposal for Systematic Classification.
Brain Sci
January 2025
Department of Surgery, Section of Neurosurgery, University of Otago, Dunedin 9016, New Zealand.
The International Classification of Diseases (ICD) has been developed and edited by the World Health Organisation and represents the global standard for recording health information and causes of death. The ICD-11 is the eleventh revision and came into effect on 1 January 2022. Perceptual disturbances refer to abnormalities in the way sensory information is interpreted by the brain, leading to distortions in the perception of reality.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!