Objective: To evaluate idiopathic hirsutism etiology via molecular studies testing peripheral and local aromatase and 5α-reductase expression.
Design: Assessment of the expression of messenger RNA (mRNA) for type 1 and 2,5α-reductase isoenzyme gene (SDR5A1, SDR5A2) and aromatase (CYP19A) in dermal papillae cells and peripheral blood mononuclear cells.
Setting: University hospital.
Patient(s): 28 untreated idiopathic hirsute patients and 20 healthy women (controls).
Intervention(s): Human skin biopsies and peripheral venous blood.
Main Outcome Measure(s): SDR5A1, SDR5A2, CYP19A gene expression in skin biopsies and peripheral blood.
Result(s): A statistically significant reduction of SRD5A1, SRD5A2, and CYP19A gene expression was found in the dermal papillae cells and peripheral blood mononuclear cell between the study and control group.
Conclusion(s): Further study, including protein expression and enzyme activity assays, are warranted to characterize the paradoxically low gene expression levels of local 5α-reductase and aromatase in women with idiopathic hirsutism.
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