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Combining quantified EEG with clinical measures to better predict outcomes of acute disorders of consciousness.
Neurophysiol Clin
January 2025
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. Electronic address:
Objective: To explore the application of the neuronal recovery model (i.e., the ABCD model derived from EEG power spectral analysis) in forecasting outcomes for patients with acute disorders of consciousness (DOC).
View Article and Find Full Text PDFRetrospective discrimination of PNES and epileptic seizure types using blood RNA signatures.
J Neurol
January 2025
Morehouse School of Medicine, Neuroscience Institute, 720 Westview Drive SW, Atlanta, GA, 30310, USA.
Objectives: The ability to differentiate epileptic- and non-epileptic events is challenging due to a lack of reliable molecular seizure biomarker that provide a retrospective diagnosis. Here, we use next generation sequencing methods on whole blood samples to identify changes in RNA expression following seizures.
Methods: Blood samples were obtained from 32 patients undergoing video electroencephalogram (vEEG) monitoring.
Lateralizing value of interictal epileptiform discharges and other parameters in hypothalamic hamartoma.
Epilepsia
January 2025
Department of Neuropediatrics and Muscular Disorders, Medical Center, Faculty of Medicine University of Freiburg, University of Freiburg, Freiburg im Breisgau, Germany.
Objective: Hypothalamic hamartomas (HHs) are associated with pharmacoresistant epilepsy. Stereotactic radiofrequency thermocoagulation (SRT) shows promise as a disconnecting intervention. Although magnetic resonance imaging (MRI) is typically used to determine the attachment and intervention side, it presents challenges in cases of bilaterally attached HH, where the epileptogenic side is unclear.
View Article and Find Full Text PDFSupplementary motor area in speech initiation: A large-scale intracranial EEG evaluation of stereotyped word articulation.
iScience
January 2025
Vivian L. Smith Department of Neurosurgery, McGovern Medical School at UT Health Houston, Houston, TX 77030, United States of America.
Speech production engages a distributed network of cortical and subcortical brain regions. The supplementary motor area (SMA) has long been thought to be a key hub in coordinating across these regions to initiate voluntary movements, including speech. We analyzed direct intracranial recordings from 115 patients with epilepsy as they articulated a single word in a subset of trials from a picture-naming task.
View Article and Find Full Text PDFLate positive potentials elicited by negative self-referential processing predict increases in social anxiety, but not depressive, symptoms from age 11 to age 12.
Dev Psychopathol
January 2025
Department of Psychology, University of Alberta, Edmonton, AB, Canada.
Social anxiety and depression exacerbate in early adolescence. Maladaptive self-referential processing confers risk for both conditions and can be assessed by the Self-Referent Encoding Task (SRET). Our cross-sectional findings indicated that the SRET-elicited anterior late positive potential (LPP) was uniquely associated with social anxiety symptoms, whereas behavioral SRET scores were uniquely associated with depressive symptoms.
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