AI Article Synopsis
- Indole derivatives, including bromoindoles, were extracted from marine sponges Rhopaloeides odorabile and Hyrtios sp.
- Their structures were determined using mass spectrometry and NMR spectroscopy, and their biological activities were assessed for PLA₂ inhibition, antioxidant capacity, and cytotoxicity.
- One notable compound, 5,6-dibromo-L-hypaphorine, exhibited weak PLA₂ inhibition and significant antioxidant activity, while the sesquiterpene aureol demonstrated the strongest antioxidant effect.
Article Abstract
Indole derivatives including bromoindoles have been isolated from the South Pacific marine sponges Rhopaloeides odorabile and Hyrtios sp. Their structures were established through analysis of mass spectra and 1D and 2D NMR spectroscopic data. Their potential inhibitory phospholipase A₂ (PLA₂), antioxidant and cytotoxic activities were evaluated. The new derivative 5,6-dibromo-L-hypaphorine (9) isolated from Hyrtios sp. revealed a weak bee venom PLA₂ inhibition (IC₅₀ 0.2 mM) and a significant antioxidant activity with an Oxygen Radical Absorbance Capacity (ORAC) value of 0.22. The sesquiterpene aureol (4), also isolated from Hyrtios sp., showed the most potent antioxidant activity with an ORAC value of 0.29.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3111189 | PMC |
| http://dx.doi.org/10.3390/md9050879 | DOI Listing |
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