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Non-contact confocal calcium imaging of murine corneal nerves.
Biomed Opt Express
January 2025
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA.
Abnormal corneal nerve function and associated disease is a significant public health concern. It is associated with prevalent ocular surface diseases, including dry eye disease. Corneal nerve dysfunction is also a common side effect of refractive surgeries, as well as a symptom of diseases that cause peripheral neuropathies.
View Article and Find Full Text PDFNociplastic pain among individuals with chronic ocular surface pain: One cause for "pain without stain"?
Surv Ophthalmol
January 2025
Michigan Medicine, Department of Ophthalmology and Visual Sciences, Ann Arbor, MI, USA.
Chronic ocular surface pain (COSP) refers to interrelated symptoms such as burning, aching, and irritation and can occur as an isolated condition or comorbid with numerous ocular disorders, including dry eye syndrome Treatments for COSP are largely aimed at the ocular surface and modulating pain arising from damaged corneal nerves; however, the average impact of these treatments on COSP are low to absent. A potential explanation for this is that, in a subset of patients with COSP, individuals have amplified and/or dysregulated neural signaling and sensory processing within the central nervous system (CNS). As in other chronic pain conditions, this might be the pathogenic mechanism primarily responsible for maintaining pain - a phenomenon now referred to as nociplastic pain.
View Article and Find Full Text PDFLaser-assisted in situ keratomileusis (LASIK) surgery for a deaf patient: Communication strategies.
Am J Ophthalmol Case Rep
March 2025
Coastal Vision Medical Group, 14726 Ramona Ave #200, Chino, CA 90708, USA.
Purpose: To report a successful method of communication with deaf patients during topical anesthetic refractive surgery.
Observations: Nonverbal ways of communicating with deaf patients during cataract surgery have been reported. Here, we present a report of LASIK surgery for a deaf patient with topical anesthesia using similar communication methods.
Efficacy and safety of transient receptor potential channel modulators for dry eye: A systematic review and meta-analysis.
Cont Lens Anterior Eye
January 2025
Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, China; Department of Integrative Medicine, Baoshan Campus of Huashan Hospital, Fudan University, Shanghai, China. Electronic address:
Purpose: To investigate the efficacy and safety of transient receptor potential (TRP) channel modulators for dry eye.
Methods: A thorough search for randomized clinical trials was conducted in seven databases up to February 16, 2024. Suitable studies were identified according to inclusion and exclusion criteria, extracted data were synthesized and analyzed using Review Manager 5.
A Novel Quaternary Ammonium N-Propylamiodarone Bromide Provides Long-Lasting Analgesia Against Corneal Pain.
Drug Des Devel Ther
December 2024
Department of Anesthesiology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, Japan.
Purpose: Corneal pain is one of the most common eye symptoms caused by various types of epithelial injuries, including traumatic abrasion, chemical injury, ulcers, ultraviolet exposure, and infection. However, current therapeutic options for corneal pain are limited. In this study, we synthesized a novel quaternary ammonium compound, N-propylamiodarone bromide (NPA), and employed a rodent model of corneal injury to investigate whether NPA offers prolonged corneal analgesia through transient receptor potential vanilloid 1 (TRPV1) channel-mediated selective cellular entry, without hindering corneal epithelial recovery.
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