Objective: This case series sought to determine the prevalence of ulnar neuropathy at the elbow (UNE) by using electrophysiologic criteria among all computer keyboard operators (CKOs) referred over a four-year period (1995-1999) for electrodiagnosis (EDX) due to clinical suspicion of focal upper limb neuropathies.
Participants: All CKOs referred to an EDX laboratory for suspicion of focal upper limb neuropathies primarily from private practice physicians, mostly hand surgeons, and an occupational medicine clinic.
Methods: All 148 CKOs underwent NCV studies of the upper limbs, which included segmental studies of the ulnar nerve and were questioned for the presence and distribution pattern of paresthesias in the symptomatic upper limb(s). The CKOs provided the electromyographer with subjective descriptions of their workstation configuration, layout, and basic office equipment.
Results: Focal ulnar neuropathy at the elbow (UNE) was identified in 105 out of 148 CKOs referred to an EDX laboratory for clinical suspicion of upper limb focal neuropathies.
Conclusions: Compared with the more prevalent diagnosis of carpal tunnel syndrome (CTS), ulnar neuropathy at the elbow should also be considered among CKOs referred for EDX testing because of suspicion of focal upper limb neuropathies. Clinicians evaluating CKOs for suspicion of focal upper limb neuropathies should routinely ask about symptoms of ulnar neuropathy.
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http://dx.doi.org/10.3233/WOR-2011-1156 | DOI Listing |
Brain
January 2025
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Nerve conduction F-wave studies contain critical information about subclinical motor dysfunction which may be used to diagnose patients with amyotrophic lateral sclerosis (ALS). However, F-wave responses are highly variable in morphology, making waveform interpretation challenging. Artificial Intelligence techniques can extract time-frequency features to provide new insights into ALS diagnosis and prognosis.
View Article and Find Full Text PDFLeprosy can present with symptoms resembling rheumatoid arthritis, leading to delays in diagnosis or inappropriate treatment, potentially progressing to lepromatous forms, neuropathy, and disability. Physicians must consider leprosy as a differential for rheumatoid arthritis, especially in endemic regions. Early detection is vital to prevent chronic neuropathy, disabilities, and disfigurement.
View Article and Find Full Text PDFJ Peripher Nerv Syst
March 2025
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Background And Aims: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is difficult to distinguish from mimicking disorders, with misdiagnosis resulting in IVIG overutilization. We evaluate a clinical-electrophysiological model to facilitate CIDP versus mimic neuropathy prediction.
Methods: Using the European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) 2021 CIDP guidelines we derived 26 clinical and 144 nerve conduction variables.
J Hand Surg Am
January 2025
Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC. Electronic address:
Purpose: Our goal was to determine the association between the severity of electrodiagnostic (EDX) studies with the cross-sectional area (CSA) of the ulnar nerve at the cubital tunnel using diagnostic ultrasound. Based on our clinical experience, we hypothesized there would not be a positive correlation between the severity of EDX and ulnar nerve CSA.
Methods: This was a retrospective analysis of patients 18 years or older evaluated from May 1, 2020, to June 31, 2021, referred for an upper limb EDX and neuromuscular ultrasound to evaluate for an upper limb neuropathy.
Int J Mol Sci
December 2024
Department of Anatomy, Cellular and Molecular Research Group, Faculty of Medicine, Masaryk University, Kamenice 3, CZ-625 00 Brno, Czech Republic.
CXCL12 and CXCR4 proteins and mRNAs were monitored in the dorsal root ganglia (DRGs) of lumbar (L4-L5) and cervical (C7-C8) spinal segments of naïve rats, rats subjected to sham operation, and those undergoing unilateral complete sciatic nerve transection (CSNT) on post-operation day 7 (POD7). Immunohistochemical, Western blot, and RT-PCR analyses revealed bilaterally increased levels of CXCR4 protein and mRNA in both lumbar and cervical DRG neurons after CSNT. Similarly, CXCL12 protein levels increased, and CXCL12 mRNA was upregulated primarily in lumbar DRGs ipsilateral to the nerve lesion.
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