Objective: The study addresses changes in the use of inpatient psychiatric treatment during the life course in various mental disorders.
Methods: We analysed inpatient admissions from a defined catchment area (1.3 mill. people) over a 1-year period by means of register data. All patients aged 15-80 referred to a psychiatric hospital in the Canton of Zurich were included in the study (9'637 inpatient admissions). To model effects of age, gender and diagnostic group we used Poisson regression analysis.
Results: In terms of the absolute number of psychiatric admissions, results suggest a peak in middle aged people (30-40 years). Nevertheless, the risk of inpatient psychiatric admission in terms of treatment prevalence (1.6 per 10'000 population) remains rather stable over the life course in both genders. On the level of specific mental disorders (ICD-10 main categories), treatment prevalence varies significantly over the life course in all diagnostic groups and, except for organic mental disorders, between both genders. From a life course perspective, data strongly suggest specific profiles of inpatient use in any mental disorder whatsoever, not only in disorders of childhood and adolescence or of ageing. In males with psychotic disorder for instance, use of inpatient treatment decreases significantly (from 6.1 to 1.0 per 10'000) after the age of 30. Only in psychotic disorders there was a significant age-by-gender interaction effect regarding the use of inpatient psychiatric treatment.
Conclusions: Neither the specific profiles of inpatient use across the life span nor the gender differences can be traced back to the morbidity rates of corresponding disorders at the respective ages, not even in serious chronic mental disorders. The findings there fore bear important implications for both clinical practice and health policy. They accentuate the need for efforts to ensure adequate treatment and continuity of care particularly for those patients at the more severe end of the spectrum of mental disorders.
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Hematol Oncol
January 2025
University of California Irvine, Irvine, California, USA.
Despite the study of BCR::ABL1-positive and -negative myeloproliferative neoplasms (MPNs) providing seminal insights into cancer biology, tumor evolution and precision oncology over the past half century, significant challenges remain. MPNs are clonal hematopoietic stem cell-derived neoplasms with heterogenous clinical phenotypes and a clonal architecture which impacts the often-complex underlying genetics and microenvironment. The major driving molecular abnormalities have been well characterized, but debate on their role as disease-initiating molecular lesions continues.
View Article and Find Full Text PDFEquine Vet J
January 2025
University of Liverpool, Institute of Life Course and Medical Sciences, Liverpool, UK.
Background: Equine odontoclastic tooth resorption and hypercementosis (EOTRH) is a painful disorder primarily affecting the incisor teeth of horses over 15 years of age. Clinical signs of the disease include prehension problems, halitosis and in severe cases weight loss. The disease predominately affects the reserve crown and presents as a loss of dental tissue and excessive build-up of cementum.
View Article and Find Full Text PDFBMC Health Serv Res
January 2025
Department of Health Sciences, University of Genoa, Via A. Pastore 1, Genoa, 16132, Italy.
Background: The rising cost of healthcare is a concerning issue for healthcare systems. The Diagnosis Related Group (DRG) system lacks direct consideration for costs related to nursing care. Therefore, to date there is no clear picture of billing models that consider also nursing activity when evaluating healthcare service costs or what factors related to nursing care affect the costs of healthcare services and would therefore need to be considered in billing models.
View Article and Find Full Text PDFJ Headache Pain
January 2025
Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, USA.
Background: Migraine progression, particularly from episodic to chronic migraine (CM), increases disease burden and healthcare costs. Understanding the new concept of "Medication Underuse Headache" should encourage the health care provider to consider early intervention with calcitonin gene-related peptide (CGRP) monoclonal antibodies. Galcanezumab given early in the course of the disease, may prevent migraine chronification and have a robust response, moreso than when initiated in later stages of migraine.
View Article and Find Full Text PDFAdv Physiol Educ
January 2025
Research for Inclusive STEM Education Center, School of Life Sciences, Arizona State University.
Academic stress is one of the primary factors threatening university students' well-being and performance. Undergraduate students who are working towards applying to medical school, defined as being on the pre-medicine or "premed" pathway, are suspected to have higher academic stress compared to their peers who are not premed. However, what factors contribute to academic stress for premed students is not well understood.
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