AI Article Synopsis
- TRPA1 is a non-selective cation channel involved in various physiological functions and is activated by chemical irritants and inflammatory compounds.
- Its role in pain and inflammation suggests that targeting TRPA1 could lead to new therapeutic options for these conditions.
- The review covers different types of molecules that act as TRPA1 agonists and antagonists, providing insights into their structure and activity.
Article Abstract
TRPA1 is a member of a superfamily of non-selective cation channels that is known to be involved in multiple physiological functions. TRPA1 is activated by a broad spectrum of chemical irritants and endogenous inflammatory compounds. An emerging role for TRPA1 in mediating pain and inflammation raises the possibility that compounds targeting TRPA1 might have significant therapeutic potential. This review discusses the broad classes of molecules that are known to act as agonists and antagonists of TRPA1 towards the aim of providing an overview of the structure and activity of TRPA1 modulators.
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| http://dx.doi.org/10.2174/156802611796904915 | DOI Listing |
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