AI Article Synopsis
- - A new method has been created for making chiral δ-lactones that have several stereocenters, focusing on making them in a specific asymmetric way.
- - The process involves multiple steps, including Evans' aldol reactions, cyclopropanation directed by hydroxyl groups, methanolysis, and reactions that use Hg(II) to open cyclopropane rings.
- - This methodology provides control over the stereochemistry of the resulting compounds, making it versatile for different applications in synthetic chemistry.
Article Abstract
A versatile methodology for the asymmetric synthesis of chiral δ-lactones containing multiple contiguous stereocenters has been developed that relies on a series of Evans' aldol, hydroxyl-directed cyclopropanation, methanolysis, and Hg(II) mediated cyclopropane ring-opening reactions for stereocontrol.
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| http://dx.doi.org/10.1021/ol2012023 | DOI Listing |
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