Transition metal complexes bearing amino linked N-heterocyclic carbenes (NHC) were prepared and evaluated for their antiproliferative activities in human cancer cells. The optimum antiproliferative activity, observed for the gold complex 3 in U-87 MG cells, was found to involve S-phase arrest of the cell cycle. The results indicate that 3 induces apoptosis through a p53-bak pathway, a finding that could serve as a new strategy to reduce the resistance of cancer cells to p53-induced apoptosis.

Download full-text PDF

Source
http://dx.doi.org/10.1021/jm101096xDOI Listing

Publication Analysis

Top Keywords

cancer cells
8
preparation characterization
4
characterization amino-linked
4
amino-linked heterocyclic
4
heterocyclic carbene
4
carbene palladium
4
palladium gold
4
gold silver
4
silver complexes
4
complexes anticancer
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!