AI Article Synopsis
- The study aimed to evaluate the effectiveness of combining rTMS with antidepressants in first-episode major depression patients.
- Sixty inpatients aged 18-45 were divided into two groups: one received citalopram with rTMS, while the other received citalopram with a sham procedure.
- Results showed the rTMS group had a significantly higher response rate (57% vs. 29%) and better cognitive improvements after two weeks, indicating that rTMS enhances the effect of citalopram.
Article Abstract
Objective: To assess the early therapeutic and cognitive effect of repetitive transcranial magnetic stimulation (rTMS) combined with antidepressant medication in treatment of first-episode patients with major depression.
Methods: Sixty first-episode depressed inpatients aged 18-45 y, who met the DSM-IV clinical criteria for major depressive episode were randomly assigned to citalopram treatment (20 mg/d) in combination with a two-week period of either rTMS (study group)or sham procedure (control group) on left dorsal-lateral prefrontal cortex (10 Hz, 90% motor threshold). The Hamilton Depression Rating Scale (HAMD) was used to assess the severity of depression. The Wisconsin Card Sorting Test (WCST) and Continuous Performance Test (CPT) were used to assess cognitive function of depression.
Result: The response rate was significantly greater in the study group compared to the control group after treatment (57% compared with 29%,P<0.05). The HAMD scores significantly declined after treatment in two groups, and the study group showed lower scores compared to the control group after 2 weeks (P<0.01). Neuropsychological assessments showed that there was no significant difference between the two groups except for the significant improvement in the categories on WCST in study group compared to the baseline (P<0.05) and the control group (P<0.05)after 2 weeks treatment. No serious event occurred in the patients during the rTMS study.
Conclusion: 10 Hz rTMS enhances early effects of citalopram and improves cognitive function in first-episode major depressive patients.
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| http://dx.doi.org/10.3785/j.issn.1008-9292.2011.03.010 | DOI Listing |
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