Objective: The goal of this study was to compare the analgesic effect of sucrose with that of the combination of sucrose and the local anesthetic cream EMLA during venipuncture in preterm neonates.
Methods: This randomized, double-blind prospective study included infants younger than 37 weeks' gestational age during 1 routine venipuncture for blood sampling. Each child randomly received either sucrose plus application of a placebo cream (S group) or sucrose plus EMLA cream (S+E group) before venipuncture. Venipuncture-induced pain was assessed through videotapes of the procedures by using the Douleur Aiguë Nouveau-né (DAN) behavioral scale. Pain was assessed at 2 phases: during venipuncture (from needle introduction to its removal) and during the recovery period (30 seconds after needle removal). Pain scores over time and between treatments were compared by using repeated-measures analysis of variance.
Results: The study included 76 children (37 in the S group, 39 in the S+E group). Mean (SD) DAN pain scores for the S group and the S+E group were 7.7 (2.1) and 6.4 (2.5), respectively, during venipuncture and 7.1 (2.8) and 5.7 (3.3) during the postinjection period. A significant time and treatment effect in favor of the S+E group was observed.
Conclusion: The combination of sucrose and EMLA cream revealed a higher analgesic effect than sucrose alone during venipuncture in these preterm infants.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1542/peds.2010-1287 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inflammatory cytokine responses in pediatric tuberculosis with or without SARS-CoV-2 seropositivity.
J Infect
December 2024
National Institutes of Health - International Center for Excellence in Research, Chennai, India; Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Objectives: To characterize the inflammatory cytokine profiles in children with TB in the presence and absence of SARS-CoV2 seropositivity.
Methods: This study evaluated cytokine responses in two groups of children with TB: CoV2+ (TB and SARS-CoV2 seropositive) and CoV2- (TB and SARS-CoV2 seronegative). Each group had 30 children, and cytokine levels were measured at baseline, months 3 and 6.
10 Cases of Nonresponse to Laser Thermoablation from a Series of 187 Patients: Histological Outcomes after Surgery and Related Evaluations.
Endocr Metab Immune Disord Drug Targets
July 2024
ASL Città di Torino S.C. Endocrinologia e Malattie del Metabolismo Turin Italy.
Background: Thyroid thermoablative techniques have been developed as an alternative to surgery for the treatment of symptomatic benign nodes, with the advantage of being minimally invasive, repeatable, with a minimal complication rate, and avoiding the perioperative risks and irreversible consequences of surgery.
Methods: A series of patients undergoing laser thermoablation by the same team of endocrinologists operating in 2 centers from May 2016 to December 2022 is presented. The procedure was performed in patients with compressive symptomatology determined by a thyroid node typed TIR 2, or TIR 3A with rejection of the surgical option.
Effects of on-site Supportive Communication Training (On-site SCT) on doctor-patient communication in oncology: Study protocol of a randomized, controlled mixed-methods trial.
BMC Med Educ
May 2024
Department of Oncology, Vejle Hospital, University Hospital of Southern Denmark, Vejle, Denmark.
Background: The quality of communication in oncology significantly impacts patients' health outcomes, as poor communication increases the risk of unnecessary treatment, inadequate pain relief, higher anxiety levels, and acute hospitalizations. Additionally, ineffective communication skills training (CST) is associated with stress, low job satisfaction, and burnout among doctors working in oncology. While acknowledging the importance of effective communication, the specific features of successful CST remain uncertain.
View Article and Find Full Text PDFNovel frameshift variant (c.409dupG) in is a common cause of congenital sideroblastic anaemia in the Indian subcontinent.
J Clin Pathol
March 2021
Department of Haematology, Christian Medical College, Vellore, Tamil Nadu, India
Aims: Congenital sideroblastic anaemias (CSAs) are a group of rare disorders with the presence of ring sideroblasts in the bone marrow. Pathogenic variants are inherited in an autosomal recessive/X-linked fashion. The study was aimed at characterising the spectrum of mutations in and genes in sideroblastic anaemia patients, exploring the genotype-phenotype correlation and identifying the haplotype associated with any recurrent mutation.
View Article and Find Full Text PDFA comparison of the free moment pattern between normal and hyper-pronated aligned feet in female subjects during the stance phase of gait.
J Biomed Phys Eng
February 2020
PhD, Rehabilitation Sciences Research Centre, Department of Physical Therapy, School of Rehabilitation Sc ences, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Excessive range of adductory free moment of the ground reaction force may potentially increase the risk of lower extremity injuries by applying a higher torsional load transmitted to the proximal parts.
Objective: It was hypothesized that the free moment pattern might be different between hyper-pronated and normal feet subjects. Moreover, a correlation would exist between peak adduction free moment and peak ankle-foot complex abduction at the stance phase of walking.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!