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Dermoscopic findings in two cases of trichogerminoma.
J Dermatol
January 2025
Department of Dermatology, Faculty of Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Trichogerminoma (TG) is a rare, benign, cutaneous adnexal tumor originating from the hair germ epithelium. It typically presents as an asymptomatic, slowly enlarging nodule predominantly on the head, face, or trunk. Despite its benign nature, precise diagnosis is crucial because of its potential to become malignant.
View Article and Find Full Text PDFDefining the needle in a haystack: A compendium of genomic, pathologic, and clinical characteristics of rare pulmonary tumors.
Lung Cancer
December 2024
Department of Internal Medicine, Division of Hematology/Oncology, Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indiana University School of Medicine (IUSOM), Indianapolis, IN 46202, USA. Electronic address:
A major paradigm shift in the diagnosis, management, and survival outcomes of early and advanced non-small cell lung cancer has transpired over the past few decades in thoracic oncology with the incorporation of molecular testing, targeted therapy, immunotherapy, neoadjuvant, and adjuvant approaches. However, transformation in the management and survival outcomes of rare lung tumors is lacking. Given the scarcity of these tumor types, randomized trials are rarely performed, and treatment is extrapolated from case series, tumor-agnostic trials, or cancers with similar histology.
View Article and Find Full Text PDFCase report: A rare case of oral sebaceous carcinoma in the upper lip.
Pathol Oncol Res
November 2024
King Abdulaziz Medical City, Prince Noorah Oncology Center, Jeddah, Saudi Arabia.
Article Synopsis
- Sebaceous carcinoma (SC) is a rare and aggressive skin cancer that develops in the sebaceous glands, with few documented cases occurring on the lips.
- A 47-year-old male smoker presented with a painless, irregularly shaped mass on his upper lip that was biopsied, revealing malignant basaloid cells with sebaceous differentiation.
- The case highlights the unique characteristics of SC, including its histogenesis and treatment options, while emphasizing the importance of further research due to its rarity.
An Atypical Presentation of Diffuse Basaloid Human Papillomavirus (HPV)-Related Squamous Cell Carcinoma of the Oral Cavity in the Setting of Prior Radiation.
Cureus
September 2024
Otolaryngology-Head and Neck Surgery, Mercy Health, Youngstown, USA.
Article Synopsis
- Basaloid squamous cell carcinoma (BSCC) is a rare, aggressive subtype of squamous cell carcinoma linked to HPV, often having better outcomes when found in the oropharynx.
- A 75-year-old woman with a history of radiation for SCC of the epiglottis presented with an unusual mucosal lesion that did not show clear masses, highlighting a rare case of HPV-related BSCC.
- The atypical appearance of the lesion can lead to delayed diagnoses, underscoring the critical need for early detection and awareness of diverse BSCC presentations to improve patient outcomes.
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