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The hidden menagerie of the posterolateral corner of the knee.
Med Ultrason
September 2024
Hacettepe University Medical School, Department of Physical and Rehabilitation Medicine, Ankara, Turkey.
Positive effect of a diggable substrate on the behaviour of a captive naked mole rat colony.
Sci Rep
August 2024
UMR 7179 MECADEV, CNRS/MNHN, Département Adaptations du Vivant, Mécanismes Adaptatifs et Evolution, Muséum National d'Histoire Naturelle, 57 Rue Cuvier, 75231, Paris, France.
Naked mole rats (Heterocephalus galber) are eusocial mammals from East Africa. Their extraordinary social organisation is accompanied by remarkable adaptations to an underground lifestyle, extreme longevity and resistance to many diseases, making naked mole rats a highly relevant model for biological research. However, their living conditions in controlled environments do not allow them to express fundamental behaviours: digging galleries and exploring.
View Article and Find Full Text PDFGastruloids: Pluripotent stem cell models of mammalian gastrulation and embryo engineering.
Dev Biol
August 2022
The Francis Crick Institute, 1 Midland Road, London, NW1 1AT, UK.
Gastrulation is a fundamental and critical process of animal development whereby the mass of cells that results from the proliferation of the zygote transforms itself into a recognizable outline of an organism. The last few years have seen the emergence of a number of experimental models of early mammalian embryogenesis based on Embryonic Stem (ES) cells. One of this is the Gastruloid model.
View Article and Find Full Text PDFA functional outside-in signaling network of proteoglycans and matrix molecules regulating autophagy.
Matrix Biol
June 2021
Department of Pathology, Anatomy, and Cell Biology, and the Translational Cellular Oncology Program, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:
Proteoglycans and selected extracellular matrix constituents are emerging as intrinsic and critical regulators of evolutionarily conversed, intracellular catabolic pathways. Often, these secreted molecules evoke sustained autophagy in a variety of cell types, tissues, and model systems. The unique properties of proteoglycans have ushered in a paradigmatic shift to broaden our understanding of matrix-mediated signaling cascades.
View Article and Find Full Text PDFLive-cell imaging in the era of too many microscopes.
Curr Opin Cell Biol
October 2020
MRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK. Electronic address:
At the time of this writing, searching Google Scholar for 'light-sheet microscopy' returns almost 8500 results; over three-quarters of which were published in the last 5 years alone. Searching for other advanced imaging methods in the last 5 years yields similar results: 'super-resolution microscopy' (>16 000), 'single-molecule imaging' (almost 10 000), SPIM (Single Plane Illumination Microscopy, 5000), and 'lattice light-sheet' (1300). The explosion of new imaging methods has also produced a dizzying menagerie of acronyms, with over 100 different species of 'light-sheet' alone, from SPIM to UM (Ultra microscopy) to SiMView (Simultaneous MultiView) to iSPIM (inclined SPIM, not to be confused with iSPIM, inverted SPIM).
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