The 2-fluoroalkoxy substituted catechol-aporphines 6, 8a-f and 11-monohydroxyaporphines 11a-e were synthesized and found to have high in vitro affinity and selectivity for the dopamine D(2) receptors. The catechol aporphines, 8b and 8d, and the monohydroxy aporphines, 11a-d, were identified as candidates for development as potential PET ligands.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110009 | PMC |
| http://dx.doi.org/10.1021/ml1001689 | DOI Listing |
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