AI Article Synopsis
- Treatment with anti-TNF-α for Crohn's disease is generally safe, but can cause skin issues like psoriasis, which may lead to discontinuation of the treatment.
- Ustekinumab, a new treatment targeting interleukin 12/23, shows promise for Crohn's disease and psoriasis.
- A case study illustrates a woman who developed psoriasis after two anti-TNF treatments but successfully managed both conditions with ustekinumab.
Article Abstract
Treatment with anti-tumor necrosis factor (TNF)-α for Crohn's disease is relatively safe, although various cutaneous adverse effects have been reported such as the development or exacerbation of anti-TNF- α-induced psoriasis, which can sometimes lead to treatment withdrawal. Therefore, new alternative treatments with new mechanisms of action are required. Ustekinumab, a monoclonal antibody against the p40 subunit of interleukin 12/23, could induce response in patients with Crohn's disease and has demonstrated efficacy in patients with psoriasis. We present the case of a woman with Crohn's disease who developed psoriasis after treatment with two anti-TNF- α drugs (infliximab and adalimumab). The patient was subsequently treated with ustekinumab with resolution or psoriasis lesions and maintenance of remission of Crohn's disease.
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| http://dx.doi.org/10.1016/j.gastrohep.2011.04.003 | DOI Listing |
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