Stereoselective synthesis of novel steroidal C-20 tertiary alcohols with thiazole and pyridine side chain using Grignard reaction of steroidal ketones and thiazole/pyridine magnesium bromide have been realized. These molecules were evaluated in vitro for their antifungal and antibacterial activities. Most of the compounds exhibited significant antifungal and antibacterial activity against all the tested strains.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejmech.2011.05.032 | DOI Listing |
Publication Analysis
Top Keywords
stereoselective synthesis
8
steroidal c-20
8
c-20 tertiary
8
tertiary alcohols
8
side chain
8
antifungal antibacterial
8
synthesis antimicrobial
4
antimicrobial activity
4
activity steroidal
4
alcohols thiazole/pyridine
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!