Phosphoenolpyruvate carboxykinase (PEPCK) governs the rate-limiting step in gluconeogenesis. Glucocorticoids and adenosine 3',5'-monophosphate (cAMP) increase PEPCK gene transcription and gluconeogenesis, whereas insulin has the opposite effect. Insulin is dominant, since it prevents cAMP and glucocorticoid-stimulated transcription. Glucocorticoid and cAMP response elements have been located in the PEPCK gene and now a 15-base pair insulin-responsive sequence (IRS) is described. Evidence for a binding activity that recognizes this sequence is presented.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1126/science.2166335 | DOI Listing |
Publication Analysis
Top Keywords
pepck gene
12
identification sequence
4
pepck
4
sequence pepck
4
gene mediates
4
mediates negative
4
negative insulin
4
insulin transcription
4
transcription phosphoenolpyruvate
4
phosphoenolpyruvate carboxykinase
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!