A feature of hospitals is that they face uncertain demand for the services they offer. To cover fluctuations in demand, they need to maintain reserve service capacity in the form of beds, equipment, personnel, etc. to minimize the probability of excess queuing or turning away patients, creating a trade-off between reserve service capacity and economic costs. Using a simple theoretical framework, we show how the reserve capacity established depends on institutional characteristics that can affect the objective of the hospital. In particular, we show that private and public hospitals may provide different levels of reserve capacity. In an empirical application using a panel data set of Spanish hospitals over the period 1996-2006, we model reserve service capacity using a distance frontier approach. Our results show that private hospitals generally react to a lesser extent to demand uncertainty than public hospitals.
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http://dx.doi.org/10.1002/hec.1755 | DOI Listing |
Int Immunopharmacol
January 2025
Immunology Laboratory of Infectious Diseases, Department of Cellular and Molecular Biology, Federal University of Paraiba, João Pessoa, Paraíba 58051-900, Brazil. Electronic address:
Obesity is a chronic inflammatory disease that affects more than 1 billion people worldwide and is associated with various metabolic and physiological dysfunctions, directly impacting the dynamics of the immune response, partly due to elevated leptin levels. Leptin is an important peptide hormone that regulates neuroendocrine function and energy homeostasis, with its blood levels reflecting energy reserves, fat mass, or energy deprivation. This hormone also plays a fundamental role in regulating immune function, including the activity of NK cells, which are essential components in antiviral and antitumor activity.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Case Western Reserve Universit, CLEVELAND, OH, USA.
Background: Mitochondrial dysfunction plays a critical role in the pathogenesis of Alzheimer's disease (AD). Mitochondrial proteostasis regulated by chaperones and proteases in each compartment of mitochondria is critical for mitochondrial function, and it is suspected that mitochondrial proteostasis deficits may be involved in mitochondrial dysfunction in AD.
Method: An unbiased screening of intraneuronal Aβ42 protein-interactome was perfumed in AD cell culture.
Food Chem
December 2024
School of Food Science and Technology, Henan University of Technology, Zhengzhou, Henan 450001, PR China.
The conductivity of Zn-MOF-on-Co-MOF synthesized by one-pot method is improved by searching for the optimum carbonization temperature, which overcomes the limitation of traditional MOF. In order to further enhance electron transfer, the mesoporous PtPdCo trimetal was introduced, which provided considerable load capacity for methylene blue (MB) and reverse complementary DNA (sDNA), and also showed excellent catalytic activity for MB. In this study, the conductivity of aptasensor was improved by modifying carbonized MOF as the base material.
View Article and Find Full Text PDFACS Omega
December 2024
Western Australia School of Mines, Minerals, Energy and Chemical Engineering, Curtin University, 26 Dick Perry Avenues, Kensington, 6151 WA, Australia.
J Colloid Interface Sci
December 2024
School of Chemistry, South China Normal University, Guangzhou 510006, China. Electronic address:
Transition metal oxides (TMOs), especially zinc- and iron-based materials, are known to be one of the most innovative anode materials based on their high theoretical capacity, low price and abundant natural reserves. However, the application of these materials is limited by poor electronic conductivity, slow ion mobility and large structural transformations during charging/discharging processes. To overcome these drawbacks, sacrificial template technology has been proposed as a promising strategy to optimize the electrochemical performance and structure stability of TMOs, showing its potential especially in the storage design of lithium-ion batteries (LIBs).
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