AI Article Synopsis
- Bone originated in vertebrates as a mineralization process around the throat or skin, leading to structures similar to teeth and protective shields in soft-bodied animals.
- Research combining fossil anatomy and modern genetics has deepened our understanding of how bone has evolved, demonstrating similarities in the molecular regulation of skin and bone even in humans.
- The article outlines key milestones in skeletal evolution and discusses genetic networks and their interactions within the framework of both historical and contemporary scientific theories.
Article Abstract
Bone is specific to vertebrates, and originated as mineralization around the basal membrane of the throat or skin, giving rise to tooth-like structures and protective shields in animals with a soft cartilage-like endoskeleton. A combination of fossil anatomy and genetic information from modern species has improved our understanding of the evolution of bone. Thus, even in man, there are still similarities in the molecular regulation of skin appendages and bone. This article gives a brief overview of the major milestones in skeletal evolution. Some molecular machineries involving members of core genetic networks and their interactions are described in the context of both old theories and modern genetic approaches.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237026 | PMC |
| http://dx.doi.org/10.3109/17453674.2011.588861 | DOI Listing |
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