Polymeric antimicrobial N-halamine epoxides.

ACS Appl Mater Interfaces

Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849, USA.

Published: August 2011

A new N-halamine copolymer has been prepared, characterized, and evaluated for antimicrobial efficacy, stability toward hydrolyses, and stability toward UVA degradation when covalently bound to cellulose fibers. A copolymer of 3-chloro-2-hydroxypropylmethacrylate and glycidyl methacrylate was coated onto cotton, and, after curing, was treated with an aqueous solution containing the potassium salt of 5,5-dimethylhydantoin to form a coating which became antimicrobial upon exposure to househod bleach (sodium hypochlorite). The coating inactivated S. aureus and E. coli O157:H7 within minutes of contact time and was quite stable toward washing and UVA photodegradation.

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http://dx.doi.org/10.1021/am200351wDOI Listing

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