AI Article Synopsis
- The study aimed to explore how body fat composition relates to metabolic syndrome (MS) and insulin resistance in women with type 1 diabetes (DM1).
- Forty-five women with DM1 participated, with 45% meeting WHO criteria for metabolic syndrome, showing that those with MS had higher central fat and lower insulin sensitivity.
- The findings suggest that assessing body fat composition can help identify DM1 patients at higher risk for metabolic issues, emphasizing the connection between central fat and insulin resistance.
Article Abstract
Objective: Our aim was to determine the relationship between body fat composition, metabolic syndrome (MS), and insulin resistance in type 1 diabetes (DM1).
Subjects And Methods: Forty-five DM1 women (36 ± 9 years; body mass index 24.6 ± 4.4 kg/m(2)) had body composition and insulin resistance determined by dual-energy X-ray absorptiometry and estimated glucose disposal ratio (eGDR), respectively. Twenty patients (45%) had MS according to World Health Organization (WHO) criteria.
Results: Women with DM1 and MS had increased central fat and lower eGDR than women without MS (41.9 ± 2.0 vs. 33.7 ± 1.8%; p = 0.004 and 4.99 ± 0.40 vs. 8.37 ± 0.39; p < 0.0001, respectively). Total body fat and peripheric fat were similar between the groups. Central fat negatively correlated with eGDR (r = -0.33; p = 0.03).
Conclusion: Central fat deposition in young non-obese DM1 women was related to MS and insulin resistance. Thus, body fat composition analysis might be important to identify DM1 patients with increased metabolic risk.
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Source |
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| http://dx.doi.org/10.1590/s0004-27302011000300003 | DOI Listing |
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