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The potential role of N-acetylcysteine as an adjuvant therapy in acute aluminum phosphide poisoning: a randomized clinical trial.
Toxicol Res (Camb)
February 2025
Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Menoufia University, Yassen Abd Al Ghafar Street, Shibin El-Kom 6132720, Egypt.
Objective: Aluminum phosphide (AP) intoxication is a life-threatening emergency with no available effective antidote. This study evaluated the efficacy and safety of N-acetylcysteine (NAC) infusion in cases of acute AP poisoning.
Methods: This randomized, single-blinded, parallel-group, controlled, clinical trial enrolled 96 patients with acute AP poisoning.
Eugenol attenuates aluminium-induced neurotoxicity in rats by inhibiting the activation of STAT3 and NF-кB.
Metab Brain Dis
January 2025
Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Article Synopsis
- Aluminium is a toxic metal that can cause serious damage to the brain, leading to inflammation and neurodegeneration.
- Eugenol, a natural compound with various health benefits, was studied for its potential to counteract the harmful effects of aluminum toxicity in rats.
- The research found that eugenol helped restore brain function and reduce damage by reversing oxidative stress and inhibiting harmful signaling pathways associated with aluminum exposure.
Co-administration of coenzyme Q10 and curcumin mitigates cognitive deficits and exerts neuroprotective effects in aluminum chloride-induced Alzheimer's disease in aged mice.
Exp Gerontol
January 2025
Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan. Electronic address:
Aluminum chloride (AlCl), a known neurotoxic and Alzheimerogenic metal disrupts redox homeostasis which plays a pivotal role in pathophysiology of neurodegenerative disorders, particularly cognitive decline. The current study was designed to unveil the long-term neuroprotective outcomes and efficacy of CoQ10 and curcumin low dose (100 mg/kg each) combination in 18-months old geriatric male Balb/c mice subjected to AlCl-prompted memory derangements (200 mg/kg in water bottles) for 28 days. The neuroprotective properties driven by antioxidant mechanisms were assessed via observing cellular pathology in key-memory related brain regions including the cornuammonis (CA3 and DG) and cortex 2/3 layer.
View Article and Find Full Text PDFBIOTECH 1766 Attenuates Oxidative Stress and Histopathological Changes following Aluminum Poisoning in ICR Mice.
Acta Med Philipp
October 2024
Department of Anatomy, College of Medicine, University of the Philippines Manila.
Objective: The aim of this study was to investigate the protective effects of BIOTECH 1766 against oxidative damage in the brain, liver, and kidneys induced by aluminum (Al) poisoning in ICR mice.
Methods: Twenty mice were divided into four groups (n = 5): (I) control, (II) Al, (III) citric acid (CA), and (IV) BIOTECH 1766 group. A 14-day treatment period was implemented, wherein groups I and II received sterile water, while groups III and IV received 10 mg/kg bw of CA and 1 x 10 cfu/kg bw of BIOTECH 1766, respectively.
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