AI Article Synopsis
- The study aimed to examine how different crystallinity levels and Ca/P ratios in hydroxyapatite (HA) granules impact biological behavior in graft materials.
- Two types of HA granules were tested: HA-1 with a lower crystallinity (28%) and HA-2 with a higher crystallinity (70%), both implanted into bone defects in rats.
- The findings indicated that both HA types were biocompatible and did not lead to significant differences in bone repair, suggesting that crystallinity does not influence the healing process in critical-sized defects.
Article Abstract
Objective: The physicochemical properties of hydroxyapatite (HA) granules were observed to affect the biological behavior of graft materials. The aim of this work was to analyze the tissue response of two HA granules with different crystallinity and Ca/P ratio in vivo.
Material And Methods: The HA granules were produced in the Biomaterials Laboratory (COPPE/UFRJ). The testing materials were HA granules presenting a Ca/P molar ratio of 1.60 and 28% crystallinity (HA-1), and a Ca/P molar ratio of 1.67 and 70% crystallinity (HA-2). Both HAs were implanted into a critical-size calvaria rat defects.
Results: To note, in the control group, the bone defects were filled with blood clot only. Descriptive and histomorphometric analyses after 1, 3, and 6 months postoperatively showed mild inflammatory infiltrate, mainly comprising macrophage-like and multinucleated giant cells, and an increase in the volume density of the fibrous tissues (p<0.05), which was in contrast to the similar volume density of the newly formed bone and biomaterials in relation to the control group.
Conclusion: Thus, we concluded that HA-1 and HA-2 are biocompatible and non-degradable, and that crystallinity does not affect bone repair of critical size defects.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223784 | PMC |
| http://dx.doi.org/10.1590/s1678-77572011005000007 | DOI Listing |
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