A platinum Chugaev carbene complex as a potent anticancer agent.

Chem Commun (Camb)

CNRS, UMR 6247, GReD Laboratory, 24 Ave des Landais, F-63177, Aubière, France.

Published: July 2011

A platinum Chugaev complex was synthesised and fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. This cis bis acyclic diamino carbene complex acts as a cytotoxic compound and behaves as a cisplatin equivalent by interacting with supercoiled DNA and thiols. Stability of the ligand is also discussed.

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Source
http://dx.doi.org/10.1039/c1cc12228bDOI Listing

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