AI Article Synopsis
- Nonalcoholic fatty liver disease (NAFLD) is a major cause of liver damage in developed countries, prompting the use of mouse models that closely mimic human disease progression.
- Research indicates that high-frequency ultrasound imaging (US) can effectively monitor liver disease progression in these mouse models, detecting changes from fat accumulation to cancerous growth.
- The findings show that US provides reliable results that align well with other assessment methods, highlighting its potential as a valuable tool for studying NAFLD and informing future treatments.
Article Abstract
Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of hepatic damage in developed countries. For this reason, mouse models of NAFLD have been developed to show progression of the disease because it perfectly resembles the human pathology. Here we show that diagnostic high-frequency ultrasound imaging (US) may be used as an effective method for monitoring the progression of liver disease, from steatosis to hepatocellular carcinoma in the methionine adenosyl transferase and glycine N-methyltransferase-deficient mice models. US reliably detected murine liver lesions associated with NAFLD in the two mice strains tested, with excellent agreement among US images, gross pathology and histological sections. Our results suggest US as a relevant approach for the study of NAFLD in mice, with interesting technical and therapeutic implications.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3118979 | PMC |
| http://dx.doi.org/10.1016/j.ultrasmedbio.2011.04.012 | DOI Listing |
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