AI Article Synopsis
- - The study aimed to analyze the frequency and distribution of killer cell immunoglobulin-like receptor (KIR) genes in the Inner Mongolian population using 90 DNA samples.
- - Results showed that certain KIR gene frequencies in Mongolian individuals were higher than those in north Mongoloid populations but lower than in Caucasians, with key haplotype findings indicating significant variations.
- - Overall, the analysis suggested that the Mongolian population exhibits genetic traits that position them between north Mongoloid and Caucasian groups, indicating influences from both populations.
Article Abstract
Objective: To investigate the killer cell immunoglobulin-like receptor (KIR) gene frequencies and genotypes distributions in the Inner Mongolian population.
Methods: Ninety genomic DNA samples were extracted from blood samples of randomly chosen Mongolian individuals. Gene-specific PCR amplification was used to identify genes present or absent for 16 KIR loci. KIR genotype distributions were obtained and compared to that of 24 populations published in literatures using principal component analysis by SAS8.0 software. Genetic tree was constructed by the calculate Nei's genetic distance.
Results: (1) The frequency of KIR 2DL2, 2DS2 in Mongolian individual is higher than that in north Mongoloid and less than that in Caucasian. (2) Haplotype AA was identified in 37.78% of individuals, which is higher than that in north Mongoloid and lower than that in Caucasian. (3) Mongolian was considered between north Mongoloid and Caucasian by principal component and genetic tree analysis.
Conclusion: Mongolian might be affected by the north Mongoloid and Caucasian, and showed intermediate between the two populations.
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| http://dx.doi.org/10.3760/cma.j.issn.1003-9406.2011.03.022 | DOI Listing |
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