Unexpected phosphodiesterase activity at low pH of a dinuclear copper-β-cyclodextrin complex.

Chem Commun (Camb)

MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, China.

Published: July 2011

A surprisingly low pK(a) (4.3) for a Cu(II) bridging water was found in the presented complex, Cu(2)L, resulting in 3 orders of magnitude higher phosphodiesterase activity on BNPP than Zn(2)L at typical lysosomal pH (~5.0).

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Source
http://dx.doi.org/10.1039/c1cc12466hDOI Listing

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