We propose and demonstrate a self-referencing alignment technique to conveniently enlarge fabricated grating area. The latent image gratings are used as the reference objects to align (adjust and lock) the attitude and position of the substrate relative to the exposure beams between and during consecutive exposures. The adjustment system and the fringe-locking system are combined into the exposure system, eliminating the drift errors between them and making the whole system low-cost and compact. For the fabricated 1 × 4 mosaics of 50 × (30 + 30 + 30 + 30) mm(2) area and 1 × 2 mosaics of 90 × (80 + 80) mm(2) area, the typical peak-valley -1st-order wavefront errors measured by a 100-mm-diameter interferometer are not more than 0.06 λ and 0.09 λ, respectively.
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http://dx.doi.org/10.1364/OE.19.008985 | DOI Listing |
The phase measuring deflectometry (PMD) method has limitations in the measurement of mirror surfaces with large local curvature, such as large integration errors and overly dense fringes. This restricts its application in the detection of complex and high-precision freeform surfaces. This paper introduces a virtual reference surface phase measuring deflectometry (VRPMD) tailored for measuring complex freeform surfaces, grounded in the concept of slope difference measurement.
View Article and Find Full Text PDFBMC Bioinformatics
February 2020
Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, 4059, Australia.
Background: Protein microarrays are a versatile and widely used tool for analyzing complex protein mixtures. Membrane arrays utilize antibodies which are captured on a membrane to specifically immobilize several proteins of interest at once. Using detection antibodies, the bound protein-antibody-complex is converted into visual signals, which can be quantified using densitometry.
View Article and Find Full Text PDFSci Rep
April 2017
Department of Precision Instrument, State Key Laboratory of Precision Measurement Technology and Instruments, Tsinghua University, Beijing, 100084, China.
Large-area holographic gratings are of great importance in diverse fields including long-range interference metrology, high-resolution astronomical telescopes, and chirped-pulse-amplification systems. However, in conventional interference lithography, the recording length is limited by the aperture of the collimating lenses. Here we propose broad-beam scanning exposure which employs the latent grating generated continuously during scanning for real-time dynamic fringe locking and thus achieves unlimited recording length.
View Article and Find Full Text PDFJ Phys Chem B
September 2015
Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
Chiral sum frequency generation spectroscopy (SFG) is of great interest for studying biological systems, among others. Whereas the chiral response in circular dichroism is about 0.1% of the achiral response, the chiral SFG response can be the same order of magnitude as the achiral SFG signal.
View Article and Find Full Text PDFOpt Express
March 2013
Electrical and Computer Engineering Department, Lehigh University, Bethlehem, Pennsylvania 18015, USA.
We report a plasmonic interferometric biosensor based on a simple slit-groove metallic nanostructure that monitors the phase changes of surface plasmon polaritons resulting from biomolecular adsorptions. The proposed sensing scheme integrates the strengths of miniaturized plasmonic architectures with sensitive optical interferometry techniques. Sensing peak linewidths as narrow as 7 nm and refractive index resolutions of 1 × 10(-5) RIU were experimentally measured from a miniaturized sensing area of 10 × 30 µm(2) using a collinear transmission setup and a low-cost compact spectrometer.
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