A series of new 16β-azolyl-3β-amino-5α-androstane derivatives were synthesized and characterized. The new compounds were screened for their anticancer activity against the human cancer cell lines SW480, A549, HepG2, HeLa and SiHa in vitro using the MTT assay. The results of the in vitro study showed that a number of compounds have shown IC(50) values lower than 20 μM against the five cancer cell lines.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejmech.2011.05.030 | DOI Listing |
Publication Analysis
Top Keywords
16β-azolyl-3β-amino-5α-androstane derivatives
8
cancer cell
8
cell lines
8
synthesis characterization
4
characterization biological
4
biological evaluation
4
evaluation 16β-azolyl-3β-amino-5α-androstane
4
derivatives potential
4
potential anticancer
4
anticancer agents
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!