The synthesis and SAR studies of a novel N-aryl pyridinone class of p38 kinase inhibitors are described. Systematic structural modifications to the HTS lead, 5, led to the identification of (-)-4a as a clinical candidate for the treatment of inflammatory diseases. Additionally, the chiral synthesis and properties of (-)-4a are described.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2011.04.121 | DOI Listing |
Publication Analysis
Top Keywords
discovery ph-797804
4
ph-797804 highly
4
highly selective
4
selective potent
4
potent inhibitor
4
inhibitor p38
4
p38 map
4
map kinase
4
kinase synthesis
4
synthesis sar
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!