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Oral Glucose-Lowering Agents vs Insulin for Gestational Diabetes: A Randomized Clinical Trial.
JAMA
January 2025
Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam Public Health Research Institute, Amsterdam, the Netherlands.
Importance: Metformin and glyburide monotherapy are used as alternatives to insulin in managing gestational diabetes. Whether a sequential strategy of these oral agents results in noninferior perinatal outcomes compared with insulin alone is unknown.
Objective: To test whether a treatment strategy of oral glucose-lowering agents is noninferior to insulin for prevention of large-for-gestational-age infants.
Cardiovascular Safety of Anti-CGRP Monoclonal Antibodies in Older Adults or Adults With Disability With Migraine.
JAMA Neurol
January 2025
Geriatric Research Education and Clinical Center, North Florida/South Georgia Veterans Health System, Gainesville, Florida.
Importance: Monoclonal antibodies (mAbs) targeting calcitonin gene-related peptide (CGRP) or its receptor (anti-CGRP mAbs) offer effective migraine-specific preventive treatment. However, concerns exist about their potential cardiovascular risks due to CGRP blockade.
Objective: To compare the incidence of cardiovascular disease (CVD) between Medicare beneficiaries with migraine who initiated anti-CGRP-mAbs vs onabotulinumtoxinA in the US.
The role of miR-155 in cardiovascular diseases: Potential diagnostic and therapeutic targets.
Int J Cardiol Cardiovasc Risk Prev
March 2025
Department of Vascular Surgery, The Affiliated Hospital, Southwest Medical University, Luzhou, 646000, China.
Cardiovascular diseases (CVDs), such as atherosclerotic cardiovascular diseases, heart failure (HF), and acute coronary syndrome, represent a significant threat to global health and impose considerable socioeconomic burdens. The intricate pathogenesis of CVD involves various regulatory mechanisms, among which microRNAs (miRNAs) have emerged as critical posttranscriptional regulators. In particular, miR-155 has demonstrated differential expression patterns across a spectrum of CVD and is implicated in the etiology and progression of arterial disorders.
View Article and Find Full Text PDFThe uses of right heart catheterization in cardio-pulmonary disease: State-of-the-art.
Am Heart J Plus
January 2025
Cardiology Division, NYU Langone Health and NYU School of Medicine, New York, NY, USA.
The right heart catheterization (RHC) remains an important diagnostic tool for a spectrum of cardiovascular disease processes including pulmonary hypertension (PH), shock, valvular heart disease, and unexplained dyspnea. While it gained widespread utilization after its introduction, the role of the RHC has evolved to provide valuable information for the management of advanced therapies in heart failure (HF) and cardiogenic shock (CS) to name a few. In this review, we provide a comprehensive overview on the indications, utilization, complications, interpretation, and calculations associated with RHC.
View Article and Find Full Text PDFLeveraging the postpartum period to reduce racial disparities in postpartum hypertension care.
Am Heart J Plus
January 2025
University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Pregnancy provides a window of opportunity for management of hypertension care. Particularly in the postpartum period - the so-called "4th trimester" - individuals of Black race are at increased risk for hypertension-related morbidity and mortality. Telehealth interventions, such as remote blood pressure monitoring programs and virtual postpartum visits, can reduce racial disparities in the delivery of recommended care.
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