[Expression of platelet-derived growth factor receptor α and its ligand PDGF- A in breast cancer].

Aim: To investigate the potential significance of platelet-derived growth factor receptor-α (PDGFR-α) and platelet-derived growth factor A (PDGF-A) expression in mammary carcinomas, and analyze its correlation with the lymph node metastasis and the expression of PDGF-A.

Methods: Used immunohistochemistry to detect the protein expression of PDGFR-α and PDGF-A in paraffinembedded breast carcinomas.

Results: The expression of PDGFR-α and PDGF-A were observed in 51.7% and 61.7% in the breast carcinomas, respectively and showed an association with lymph node metastasis (P < 0. 05). A correlation was also found with the expression of PDGFR-α and PDGF-A (P<0.05).

Conclusion: PDGFR-α is expressed in invasive breast carcinomas and is associated with biological aggressiveness.