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Revisiting Age-Related Normative Hearing Levels in Korea.
J Korean Med Sci
January 2025
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, Hanyang University, Seoul, Korea.
Background: Hearing level reference values based on the results of recent audiometry have not been established for the general population of South Korea. This study aimed to evaluate the mean hearing levels of each age group and to measure the annual progression of hearing loss.
Methods: We used the database of the eighth and ninth Korea National Health and Nutrition Examination Survey from 2020 to 2022, and included participants with normal tympanic membranes and without occupational noise exposure.
Global, regional, and national burden of esophageal cancer: a systematic analysis of the Global Burden of Disease Study 2021.
Biomark Res
January 2025
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, 200032, China.
Background And Objective: Esophageal cancer (EC) is the seventh most prevalent cancer globally and the sixth leading cause of cancer-related mortality. This study aimed to provide an updated stratified assessment of rates in EC incidence, mortality, and disability-adjusted life-years (DALYs) from 1990 to 2021 by sex, age, and Socio-demographic Index (SDI) at global, regional, and national levels, as well as to project the future trends of EC both globally and regionally.
Methods: Data about age-standardized rates (ASRs) of incidence (ASIR), mortality (ASDR), probability of death (ASPoD) and DALYs (ASDALYRs) of EC were obtained from the 2021 Global Burden of Disease (GBD) study.
Fragment-to-Lead Medicinal Chemistry Publications in 2023.
J Med Chem
January 2025
Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom.
This Perspective summarizes successful fragment-to-lead (F2L) studies that were published in 2023 and is the ninth installment in an annual series. A tabulated summary of the relevant articles published in 2023 is provided (17 entries from 16 articles), and a comparison of the target classes, screening methods, and overall fragment or lead property trends for 2023 examples and for the combined entries over the years 2015-2023 is discussed. In addition, we identify several trends and innovations in the 2023 literature that promise to further increase the success of fragment-based drug discovery (FBDD), particularly in the areas of NMR and virtual screening, fragment library design, and fragment linking.
View Article and Find Full Text PDFPerspective: Incidence of Clinician-Diagnosed Lyme Disease in Manitoba, Canada 2009-2018.
Vector Borne Zoonotic Dis
January 2025
Infectious Diseases and Vaccine Programs Branch, Public Health Agency of Canada, Saint-Hyacinthe, Canada.
Article Synopsis
- Lyme disease (LD) surveillance in Manitoba faces challenges, including underreporting, which affects the understanding of disease trends and distribution.
- A retrospective analysis from 2009 to 2018 identified 1,658 clinician-diagnosed LD cases from over 1.6 million registrants, with the majority occurring during peak tick activity (May to July).
- Annualized findings revealed a mean incidence of 10.17 cases per 100,000 people, significantly higher than the 30 cases reported by the Manitoba Health surveillance system, highlighting the extent of underreporting.
Social and Polygenic Risk Factors for Time to Comorbid Diagnoses in Individuals with Substance Use Disorders: A Phenome-Wide Survival Analysis.
medRxiv
December 2024
SUNY Downstate Health Sciences University, Department of Psychiatry and Behavioral Sciences.
Importance: Persons with substance use disorders (SUD) often suffer from additional comorbidities, including psychiatric conditions and physical health problems. Researchers have explored this overlap in electronic health records (EHR) using phenome wide association studies (PheWAS) to characterize how different indicators are related to all conditions in an individual's EHR. However, analyses have been largely cross-sectional in nature.
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