AI Article Synopsis
- Patients with Gilbert syndrome have a malfunctioning enzyme (UGT1A1) that affects the breakdown of carcinogenic 4-OH-estrogens, which are derived from estrogen degradation.
- This condition may lead to an increased accumulation of 4-OH-estrogens in patients, potentially raising their risk for developing breast cancer, particularly in individuals exposed to elevated estrogen levels.
- If proven, this could identify a new risk group for breast cancer and provide valuable insights into the mechanisms behind breast cancer development.
Article Abstract
Patients with Gilbert syndrome have an impaired function of the enzyme UGT1A1, responsible for the degradation of 4-OH-estrogens. These elements are produced by the degradation of estrogens and are well-known carcinogens. In theory, patients with Gilbert syndrome accumulate 4-OH-estrogens and, therefore, might have a higher risk for breast cancer, especially when exposed to higher levels of estrogens. If this theory is true, a new risk group for breast cancer would be described, producing new insights in breast carcinogenesis.
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| http://dx.doi.org/10.1016/j.mehy.2011.03.047 | DOI Listing |
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