Granular cell tumors (GCT) are infrequent tumors first described by Abrikossoff in 1926. Gastrointestinal involvement occurs in about 6% of GCT, the esophagus being the most frequent location. These tumors are usually benign and asymptomatic and are usually found incidentally when an upper gastrointestinal endoscopy is carried out for another reason, showing an isolated polyp or sessile submucosal nodule, covered by intact yellowish mucosa and with firm consistency. Endoscopic ultrasonography has significantly improved the diagnosis of these lesions. Nowadays endoscopic mucosectomy is the treatment of choice of esophageal GCT with a low frequency of complications. Histologic analysis of the surgical specimen shows specific characteristics such as positivity for S-100 protein. We present two new cases of esophageal GCT that were diagnosed recently and discuss the most relevant features of this infrequent disease.
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Endoscopic resection for esophageal granular cell tumors: report of 62 cases.
BMC Gastroenterol
November 2024
Endoscopy Center, Zhongshan Hospital of Fudan University, Shanghai, 200032, China.
Background: To analyze the clinical manifestations, endoscopic features, pathological features, endoscopic resection, and prognosis of esophageal granular cell tumors (GCTs).
Methods: The present study retrospectively analyzed and followed up the clinical data of 62 patients diagnosed with esophageal GCTs who underwent endoscopic resection at Zhongshan Hospital of Fudan University between July 2007 and March 2022. The clinicopathological features, endoscopic diagnosis, and treatment experience of esophageal GCT patients were summarized.
Perioperative gum-chewing training prevents a decrease in tongue pressure after esophagectomy in thoracic esophageal cancer patients: a nonrandomized trial.
Sci Rep
October 2024
Department of Preventive Dentistry, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2-5-1, Shikata-cho, Kita-ku, Okayama-shi, Okayama, 700-8558, Japan.
Article Synopsis
- Tongue pressure (TP) significantly drops in esophageal cancer patients after esophagectomy, but gum-chewing training (GCT) has been shown to boost TP in healthy individuals.
- This study tested whether perioperative GCT could lower the rate of TP decline and mitigate complications in thoracic esophageal cancer patients post-surgery.
- Results showed that only 44% of patients in the gum-chewing group experienced reduced TP after surgery, compared to 76% in the historical control group, and the gum-chewing group also had fewer fever days post-operation.
Esophageal granular cell tumors (GCTs) are rare mesenchymal neoplasms that originate from the Schwann cells of the neural sheath in the esophageal wall. Esophageal GCTs represent approximately 2% of all GCTs. Most cases of esophageal GCT occur in adults with few cases reported in pediatric patients.
View Article and Find Full Text PDFGastrointestinal Tract Granular Cell Tumor in the Pediatric Population: A Multicenter Experience.
Pediatr Dev Pathol
May 2024
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
Background: Pediatric granular cell tumors (GCT) involving the gastrointestinal tract (GIT) are rare with limited case report/series reported to date.
Methods: Multicenter retrospective study of pediatric GIT GCT.
Results: A total of 10 cases were included in the study with a median age of 13.
Esophageal Granular Cell Tumor: An Uncommon Cause of Dysphagia.
Cureus
July 2023
Pathology, Orlando Veterans Affairs Medical Center, Orlando, USA.
Granular cell tumors (GCTs) are rare, typically benign, solitary neoplasms that can arise throughout the body, with reports of cases in the tongue, esophagus, colon, skin, vulva, and skeletal muscle, among others. Although GCTs are usually asymptomatic, esophageal GCTs can grow large enough to cause dysphagia. When developing the differential diagnosis for dysphagia, a broad consideration includes routine etiologies such as esophageal strictures, eosinophilic esophagitis, carcinoma, webs and rings, achalasia, and motility disorders, but GCTs may not readily come to mind.
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