AI Article Synopsis
- Eight new sesquiterpene alkaloids (1-8) and four known alkaloids (9-12) were isolated from the roots of Maytenus mekongensis, with their structures identified through various spectroscopy techniques.
- The configuration of one compound, 7-epi-mekongensine (2), was confirmed using single-crystal X-ray crystallography.
- The isolated alkaloids were tested for their effectiveness against Plasmodium falciparum (the malaria parasite) and assessed for cytotoxicity in different cell lines.
Article Abstract
Eight new sesquiterpene alkaloids (1-8) and four known sesquiterpene alkaloids (9-12) have been isolated from the roots of Maytenus mekongensis. Structures were determined using extensive spectroscopic methods. The relative configuration of 7-epi-mekongensine (2) was established by single-crystal X-ray crystallographic analysis. The alkaloids were evaluated for antiplasmodial activity against Plasmodium falciparum, K1 strain, and for cytotoxicity using a panel of cell lines.
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| http://dx.doi.org/10.1021/np200014k | DOI Listing |
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