Clonorchis sinensis, or Chinese liver fluke, is a parasite of the fish-eating mammals endemic in the East Asia, Far East, particularly in China, Japan, Taiwan, Vietnam, and Korea and among immigrant refugees to European Union and Eastern Mediterranean Countries. This paper reported infection among Egyptian family who practice consumption of imported fishes from the Far East. Diagnosed was based on detection of its characteristic eggs, positive specific ELISA, radiological and family behavior and feeding habit history. Patients were successfully treated.

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Article Synopsis
  • Clonorchis sinensis infection significantly worsens overall survival rates in patients with intrahepatic cholangiocarcinoma (ICC) compared to those without the infection.
  • Researchers used RNA sequencing and animal models to investigate how C. sinensis infection facilitates the progression of ICC.
  • The study found that C. sinensis infection leads to increased expression of fatty acid synthase (FASN), which promotes fatty acid synthesis and tumor growth, suggesting a potential new target for treatment in ICC patients infected with C. sinensis.
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: Clonorchiasis is a foodborne parasitic disease that can lead to severe biliary fibrosis and cholangiocarcinoma. While praziquantel (PZQ) is available for clonorchiasis treatment, it cannot revert the histopathological damage incurred through parasite-induced fibrosis. Curcumin (CUR) is an emerging experimental drug possessing anti-inflammatory and fibrosis-alleviating effects, thus signifying its potential as an anthelmintic drug.

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Assessment of the application of the FA280-a fully automated fecal analyzer for diagnosing clonorchiasis: a mixed-method study.

Infect Dis Poverty

January 2025

Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.

Background: Clonorchiasis is an important foodborne parasitic disease in China caused by Clonorchis sinensis. Accurate and rapid diagnosis of this disease is vital for treatment and control. Traditional fecal examination methods, such as the Kato-Katz (KK) method, are labor-intensive, time-consuming, and have limited acceptance.

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Correlation analysis of the impact of juvenile on gut microbiota and transcriptome in mice.

Microbiol Spectr

December 2024

Department of Cell Biology and Genetics, School of Basic Medical Sciences, Guangxi Medical University, Nanning, China.

Unlabelled: remains a non-negligible global zoonosis, imposing serious socio-economic burdens in endemic regions. The interplay between gut microbiota and the host transcriptome is crucial for maintaining health; however, the impact of juvenile infection on these factors is still poorly understood. This study aimed to investigate their relationship and potential pathogenic mechanisms.

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The cognition, behaviours and social environment related to Clonorchis sinensis infection in China: a qualitative study.

Trans R Soc Trop Med Hyg

December 2024

Department of Medical Statistics, School of Public Health, Sun Yat-sen University, 74 Zhongshan 2nd Road, 510080, Yuexiu District, Guangzhou, Guangdong Province, People's Republic of China.

Background: Cognition, behaviours and social environment are associated with Clonorchis sinensis infection, a prevalent liver fluke disease in China. This study aimed to use social cognitive theory (SCT) to investigate these three aspects and their interaction in an endemic area.

Methods: We conducted three semi-structured focus group discussions in Da'ao town, Jiangmen city, Guangdong Province, China.

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