A single-input whispering gallery optical microbubble resonator is presented. Spherical microbubbles with diameters less than 100 μm, micrometer-sized wall thicknesses, and a single opening or input were fabricated by heating the tapered tip of a pressurized glass capillary using a CO(2) laser. Optical whispering gallery modes with Q factors of ∼10(5) were obtained. The bubbles were filled with water and mode shifts of ∼20 GHz were observed. Fano-type resonances were detected when the coupling optical fiber diameter was less than 1 μm, causing the microresonator to switch from being a band-stop filter to a bandpass filter. Larger bubbles with submicrometer wall thickness were also fabricated.
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http://dx.doi.org/10.1364/OL.36.002113 | DOI Listing |
Cancers (Basel)
December 2024
Department of Diagnostic Imaging, Oncologic Radiotherapy and Hematology, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00100 Rome, Italy.
The growing interest in minimal and non-invasive therapies, especially in the field of cancer treatment, highlights a significant shift toward safer and more effective options. Ablative therapies are well-established tools in cancer treatment, with known effects including locoregional control, while their role as modulators of the systemic immune response against cancer is emerging. The HIFU developed with magnetic resonance imaging (MRI) guidance enables treatment precision, improves real-time procedural control, and ensures accurate outcome assessment.
View Article and Find Full Text PDFProc Inst Mech Eng H
January 2025
Department of Medical Sciences & Technology, IIT Madras, Chennai, Tamil Nadu, India.
The use of ultrasound contrast agents (UCAs) for estimating portal pressure has recently gained attention due to its clinical promise, yet variability in acoustic amplitude poses challenges. UCAs contain microbubbles (1-10 µm in diameter), and understanding their acoustic response is essential to address this variability. However, systematic exploration of factors influencing microbubble behavior remains limited in current literature.
View Article and Find Full Text PDFUltrasonics
December 2024
Department of Physics, Concordia University, Montreal, Quebec H4B 1R6, Canada; Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada. Electronic address:
Clinical ultrasound contrast agent microbubbles remain intravascular and are between 1-8 µm in diameter, with a volume-weighted mean size of 2-3 µm. Despite their worldwide clinical utility as a diagnostic contrast agent, and their continued and ongoing success as a local therapeutic vector, the fundamental interplay between microbubbles - including bubble-bubble interaction and the effects of a neighboring viscoelastic vessel wall, remain poorly understood. In this work, we developed a finite element model to study the physics of the complex system of two different-sized bubbles (2 and 3 µm in diameter) confined within a viscoelastic vessel from a resonance response perspective (3-12 MHz).
View Article and Find Full Text PDFLab Chip
December 2024
College of Engineering and Applied Sciences, Nanjing University, Jiangsu 210093, China.
Acoustic waves provide an effective method for object manipulation in microfluidics, often requiring high-frequency ultrasound in the megahertz range when directly handling microsized objects, which can be costly. Micro-air-bubbles in water offer a solution toward low-cost technologies using low-frequency acoustic waves. Owing to their high compressibility and low elastic modulus, these bubbles can exhibit significant expansion and contraction in response to even kilohertz acoustic waves, leading to resonances with frequencies determined and tuned by air-bubble size.
View Article and Find Full Text PDFUltrason Sonochem
January 2025
Toronto Metropolitan University, 350 Victoria Street, Toronto, Ontario, Canada; Institute for Biomedical Engineering, Science and Technology (iBEST), a partnership between St. Michael's Hospital and Toronto Metropolitan University, 209 Victoria St, Toronto, Ontario, Canada.
This study presents an experimental investigation of the influence of MB concentration on the resonance frequency of lipid-coated microbubbles (MBs). Expanding on theoretical models and numerical simulations from previous research, this work experimentally investigates the effect of MB size on the rate of resonance frequency increase with concentration, a phenomenon observed across MBs with two different lipid compositions: propylene glycol (PG) and propylene glycol and glycerol (PGG). Employing a custom-designed ultrasound attenuation measurement setup, we measured the frequency-dependent attenuation of MBs, isolating MBs based on size to generate distinct monodisperse sub-populations for analysis.
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