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| http://dx.doi.org/10.1167/iovs.11-7371 | DOI Listing |
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rsfMRI-based brain entropy is negatively correlated with gray matter volume and surface area.
Brain Struct Funct
January 2025
Department of Diagnostic Radiology & Nuclear Medicine, University of Maryland School of Medicine, 670 W Baltimore St, HSF III, R1173, Baltimore, MD, 21202, USA.
The brain entropy (BEN) reflects the randomness of brain activity and is inversely related to its temporal coherence. In recent years, BEN has been found to be associated with a number of neurocognitive, biological, and sociodemographic variables such as fluid intelligence, age, sex, and education. However, evidence regarding the potential relationship between BEN and brain structure is still lacking.
View Article and Find Full Text PDFOptogenetics has transformed the study of neural circuit function, but limitations in its application to species with large brains, such as non-human primates (NHPs), remain. A major challenge in NHP optogenetics is delivering light to sufficiently large volumes of deep neural tissue with high spatiotemporal precision, without simultaneously affecting superficial tissue. To overcome these limitations, we recently developed and tested in NHP cortex, the Utah Optrode Array (UOA).
View Article and Find Full Text PDFBackground: Metabolic processes form the basis of the development, functioning and maintenance of the brain. Despite accumulating evidence of the vital role of metabolism in brain health, no study to date has comprehensively investigated the link between circulating markers of metabolic activity and in vivo brain morphology in the general population.
Methods: We performed uni- and multivariate regression on metabolomics and MRI data from 24,940 UK Biobank participants, to estimate the individual and combined associations of 249 circulating metabolic markers with 91 measures of global and regional cortical thickness, surface area and subcortical volume.
As more powerful high performance computing resources are becoming available, there is a new opportunity to bring the unique capabilities of molecular dynamics (MD) simulations to cell-scale systems. Membranes are ubiquitous within cells and are responsible for a diverse set of essential biological functions, but building atomistic models of cell-scale membranes for MD simulations is immensely challenging because of their vast sizes, complex geometries, and complex compositions. To meet this challenge, we have developed xMAS Builder (E perimentally-Derived embranes of rbitrary hape Builder), which is designed to take experimental lipidomics and structural (e.
View Article and Find Full Text PDFEvaluation of the Effectiveness of Using LED Light Combined With Chromophore Gel in Treating Acne Vulgaris - Preliminary Study.
Clin Cosmet Investig Dermatol
January 2025
Department of Basic Biomedical Science, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia in Katowice, Sosnowiec, Poland.
Purpose: The aim was to quantitatively evaluate the effectiveness of LED light therapy combined with photoacceptor substances having anti-acne properties in reducing the symptoms of acne vulgaris.
Patients And Methods: 15 subjects aged 20 to 24 who suffered from moderate or severe acne lesions. The treatments were performed using a LED device (465-880 nm).
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